Importantly, hypervirulent clinical M. The most recently evolved type VII secretion system, ESX-5, secretes dozens of substrates belonging to the PE and PPE families, which are named for conserved proline and glutamic acid residues close to the amino terminus3,4. The most recently evolved type VII secretion system, ESX-5, secretes dozens of substrates belonging to the PE and PPE families, which are named for conserved proline and glutamic acid residues close to the amino terminus 3,4. This indicates that these ESX-5 substrates have an important role in virulence attenuation. Restoration of PPEdependent secretion partially reverted the hypervirulence phenotype of a Beijing strain, and deletion of ppe38 in moderately virulent M.
Ates, Louis S. Most of these proteins are transported by the different type VII secretion systems1,2. The most recently evolved type VII secretion system, ESX-5, secretes dozens of substrates belonging to the PE and PPE families, which are named for conserved proline and glutamic acid residues close to the amino terminus3,4.
However, the role of these proteins remains largely elusive1. Importantly, hypervirulent clinical M. Restoration of PPEdependent secretion partially reverted the hypervirulence phenotype of a Beijing strain, and deletion of ppe38 in moderately virulent M.
This indicates that these ESX-5 substrates have an important role in virulence attenuation. Most of these proteins are transported by the different type VII secretion systems 1,2.
The most recently evolved type VII secretion system, ESX-5, secretes dozens of substrates belonging to the PE and PPE families, which are named for conserved proline and glutamic acid residues close to the amino terminus 3,4. However, the role of these proteins remains largely elusive 1.
Phylogenetic analysis revealed that deletion of ppe38 occurred at the branching point of the 'modern' Beijing sublineage and is Fatting Fat Burn Chart by Beijing outbreak strains worldwide, suggesting that this deletion may have contributed to their success and global distribution 6,7.